The molecular weight range of low molecular weight HA (LMW-HA) is yet to be defined to a uniform standard. It usually ranges from 3000 to 1 million. Research shows that HA’s various biological activities are molecular weight dependent, some of LMW-HA’s biological activities are not reflected in high molecular weight HA which would have the opposite effect.

Low molecular weight HA in the human body has a role in promoting angiogenesis, also a role of immune activation and promotion of bone formation. In vitro it can promote proliferation of endothelial cell. At the same time there are research data suggesting that low molecular weight HA is easier to penetrate into the dermis than the high molecular weight HA in the skin absorption. It promotes blood circulation, regulates skin metabolism, improves skin nutrition, and plays a wrinkle beauty care.

Compared with the high molecular weight HA, LMW-HA may show different biological functions. It can stimulate angiogenesis and induce the expression of inflammatory mediators, inhibit the proliferation of tumor, has the antibacterial effect and so on. Therefore, how to produce LMW-HA has become a research hotspot. Our company adopts special crafts to make LMW-HA. HA with different molecular weight can be customized. The minimum molecular weight is 3000. Our HA 3000 has a good reputation in Japanese market already.